Yes, and you can change it many times. But first, you should add new employee's information in People.
Read more: How to Add New Employees?
Next, go to Payroll > Pay Run > Double click the draft you want to change > Click on Add in the step 2
Read more:
Pay Run: One-time/Add new
How to Set Up a Commission or Bonus Pay Item?
How to Add Different Fixed Pay Items to Employees Included in Same Payroll Policy?